Wednesday, July 5th
08,30-09,50
REGISTRATION
09,50-10,00
Introductory remarks by Giuseppina De Simone and Claudiu T. Supuran
SESSION I
PL1
Claudiu T. Supuran
A 90-year old ever young enzyme
11,00-11,30
COFFEE BREAK
11,30-12,00
K1
Seppo Parkkila
Carbonic anhydrases as targets for treatment of parasitic diseases
12,00-12,20
O1
Silvia Pastorekova
Carbonic anhydrases in cancer: focus on CA IX as therapy target
12,20-12,40
O2
Stephanie Gros
Preclinical targeting of CA IX in patient-derived cancer models
12,40-15,00
LUNCH
Chair: Seppo Parkkila
15,00-15,30
K2
Fabrizio Carta
Carbonic anhydrase based approach for multi targeting purposes: are we doing right?
15,30-16,00
K3
Roberto Ronca
Targeting carbonic anhydrases in cancer
16,00-16,20
O3
Antonio Randazzo
DNA G-quadruplexes and carbonic anhydrases: new targets for multi-target-directed-ligands
16,20-16,50
COFFEE BREAK
Chair: Vincenzo Alterio
16,50-17,20
K4
Simone Carradori
BacCAD project, searching for new antibacterial agents: MedChem efforts to develop selective carbonic anhydrase inhibitors with anti-Helicobacter pylori activity
17,20-17,40
O4
Thor Eysteinsson
Carbonic anhydrase inhibitors and vascular function
17,40-18,00
O5
Maria Elena Russo
Carbonic anhydrase as an industrial biocatalyst for CO2 capture processes
Thursday, July 6th
SESSION II
Chairs: Marianna Patrauchan and Jean-Yves Winum
9,00-9,30
K5
Shoukat Dedhar
Co-targeting CAIX and xCT/GPX-4 to induce Ferroptosis in hypoxic tumor cells
9,30-10,00
K6
Sébastien Thibaudeau
Superacid mediated synthesis of carbonic anhydrase inhibitors
10,00-10,20
O6
Tiziano Tuccinardi
Compose, manage and analyze chemical-based databases
10,20-10,40
O7
Bogdan Iorga
Molecular docking for the design of isozyme selective carbonic anhydrase inhibitor
10,40-11,00
O8
Giannamaria Annunziato
Discovering a new class of pyrazine n-oxide that selectively inhibit microbial carbonic anhydrases
11,00-11,30
COFFEE BREAK
11,30-12,00
K7
Jean-Yves Winum
Carbonic anhydrase-targeted approach for photodynamic therapy
12,00-12,20
O9
Junming Ho
Predicting carbonic anhydrase inhibitor affinities – Do pKa values matter?
12,20-12,40
O10
Alessio Nocentini
Carbonic anhydrase modulators as multitarget-directed ligands to treat multifactorial disorders
12,40-13,00
O11
Stefano Alcaro
Drug design of multi-targeting agents involving carbonic anhydrases
13,00-15,00
LUNCH
15,00-16,00
POSTER SESSION
YOUNG SESSION I
16,00-16,15
Y1
Emanuela Berrino
Fluorinated (di) amines act as hCA IV inhibitors: exploring the fluorine impact on enzyme inhibition selectivity
16,15-16,30
Y2
Gustavo Provensi
Brain carbonic anhydrase activity modulates social recognition memory
16,30-16,45
Y3
Davide Esposito
The biocatalytic potential of CDCA1 from Thalassiosira weissflogii: exploring the selective hydrolysis of CO2 and CS2 through rational mutagenesis
16,45-17,00
Y4
Alessandro Bonardi
Dual cholinesterase and carbonic anhydrase inhibitors for a multi-target approach to treat Alzheimer’s disease
17,00-17,15
Y5
Annachiara Sarnella
Targeting CA IX to overcome hypoxia-induced chemoresistance
17,15-17,30
Y6
Wagdy Eldehna
Bioisosteric replacement of SLC-0111 tail with privileged heterocycles to afford novel anticancer agents
20,00
SOCIAL DINNER
Friday, July 7th
SESSION III
Chair: Claudiu T. Supuran
9,00-9,30
K8
Marc Ilies
Novel lipophilic CA IX inhibitors as efficient therapeutic agents for ovarian cancer
9,30-9,50
O12
Silvia Fossati
Inhibiting carbonic anhydrases ameliorates Alzheimer’s disease pathology by restoring cerebrovascular function and reducing inflammation
9,50-10,10
O13
Marianna Patrauchan
Understanding functional roles of β- and γ-Carbonic anhydrases in Pseudomonas aeruginosa
10,10-10,30
O14
Raivis Zalubovskis
From natural product inspired to artificial design of carbonic anhydrase inhibitors
10,30-11,00
Chairs: Marc Ilies and Raivis Zalubovskis
11,00-11,30
K9
Clemente Capasso
Links between carbonic anhydrase and bacterial metabolism: an opportunity to discover antibacterials
11,30-12,00
K10
William Alexander Donald
Effects of phosphorylation on the activity, inhibition and stability of carbonic anhydrases
12,00-12,20
O15
Ashok Aspatwar
Bicarbonate and bacteria: friends or foes?
12,20-12,40
O16
Hany Ibrahim
Flexible and non-flexible linkers between Zn binding group and tail scaffold in tumor-associated CA inhibitors: a cumulative study
12,40-15,00
LUNCH
YOUNG SESSION II
Chairs: Simone Carradori and Emma Langella
15,00-15,15
Y7
Vincenzo Massimiliano Vivenzio
Unveiling the secrets of γ-carbonic anhydrases in Pseudomonas aeruginosa: structural and biochemical discoveries
15,15-15,30
Y8
Andrea Angeli
Inhibition of carbonic anhydrases as a potential strategy for neuropathic pain management
15,30-15,45
Y9
Paolo Guglielmi
Coumalic acid derivatives as selective inhibitors of human carbonic anhydrase IX and XII: design, synthesis, biological and molecular modeling studies
15,45-16,00
Y10
Sara Amiranda
Loss-of-function analysis of carbonic anhydrase IX in neuronal models
16,00-16,30
Chairs: Martina Buonanno and Alessio Nocentini
16,30-16,45
Y11
Ilaria D’Agostino
Hybridization strategy applied to antimalarial drug design: towards Artesunate derivatives as inhibitors of P. falciparum carbonic anhydrase
16,45-17,00
Y12
Damiano Tanini
Carbonic anhydrase modulation and glutathione peroxidase imitation: mechanistic insights into the dual activity of chalcogen-containing small molecules
17,00-17,15
Y13
Simone Giovannuzzi
Development of oxazolidinone-based carbonic anhydrase inhibitors as novel antibiotics against gram-positive bacteria
17,15-17,30
YOUNG AND POSTER SESSION AWARDS
17,30-17,40
Conclusive remarks by Giuseppina De Simone and Claudiu T. Supuran
