CONFERENCE PROGRAMME

Wednesday, July 5th

08,30-09,50

REGISTRATION

09,50-10,00

Introductory remarks by Giuseppina De Simone and Claudiu T. Supuran

SESSION I

Chair: Giuseppina De Simone
10,00-11,00

PL1

Claudiu T. Supuran
A 90-year old ever young enzyme

11,00-11,30

COFFEE BREAK

Chairs: William Alexander Donald and Simona Maria Monti

11,30-12,00

K1

Seppo Parkkila
Carbonic anhydrases as targets for treatment of parasitic diseases

12,00-12,20

O1

Silvia Pastorekova
Carbonic anhydrases in cancer: focus on CA IX as therapy target

12,20-12,40

O2

Stephanie Gros
Preclinical targeting of CA IX in patient-derived cancer models

12,40-15,00

LUNCH

Chair: Seppo Parkkila

15,00-15,30

K2

Fabrizio Carta
Carbonic anhydrase based approach for multi targeting purposes: are we doing right?

15,30-16,00

K3

Roberto Ronca
Targeting carbonic anhydrases in cancer

16,00-16,20

O3

Antonio Randazzo
DNA G-quadruplexes and carbonic anhydrases: new targets for multi-target-directed-ligands

16,20-16,50

COFFEE BREAK

Chair: Vincenzo Alterio

16,50-17,20

K4

Simone Carradori
BacCAD project, searching for new antibacterial agents: MedChem efforts to develop selective carbonic anhydrase inhibitors with anti-Helicobacter pylori activity

17,20-17,40

O4

Thor Eysteinsson
Carbonic anhydrase inhibitors and vascular function

17,40-18,00

O5

Maria Elena Russo
Carbonic anhydrase as an industrial biocatalyst for CO2 capture processes

Thursday, July 6th

SESSION II

Chairs: Marianna Patrauchan and Jean-Yves Winum

9,00-9,30

K5

Shoukat Dedhar
Co-targeting CAIX and xCT/GPX-4 to induce Ferroptosis in hypoxic tumor cells

9,30-10,00

K6

Sébastien Thibaudeau
Superacid mediated synthesis of carbonic anhydrase inhibitors

10,00-10,20

O6

Tiziano Tuccinardi
Compose, manage and analyze chemical-based databases

10,20-10,40

O7

Bogdan Iorga
Molecular docking for the design of isozyme selective carbonic anhydrase inhibitor

10,40-11,00

O8

Giannamaria Annunziato
Discovering a new class of pyrazine n-oxide that selectively inhibit microbial carbonic anhydrases

11,00-11,30

COFFEE BREAK

Chairs: Fabrizio Carta and Katia D’Ambrosio

11,30-12,00

K7

Jean-Yves Winum
Carbonic anhydrase-targeted approach for photodynamic therapy

12,00-12,20

O9

Junming Ho
Predicting carbonic anhydrase inhibitor affinities – Do pKa values matter?

12,20-12,40

O10

Alessio Nocentini
Carbonic anhydrase modulators as multitarget-directed ligands to treat multifactorial disorders

12,40-13,00

O11

Stefano Alcaro
Drug design of multi-targeting agents involving carbonic anhydrases

13,00-15,00

LUNCH

15,00-16,00

POSTER SESSION

YOUNG SESSION I

Chairs: Clemente Capasso and Anna Di Fiore

16,00-16,15

Y1

Emanuela Berrino
Fluorinated (di) amines act as hCA IV inhibitors: exploring the fluorine impact on enzyme inhibition selectivity

16,15-16,30

Y2

Gustavo Provensi
Brain carbonic anhydrase activity modulates social recognition memory

16,30-16,45

Y3

Davide Esposito
The biocatalytic potential of CDCA1 from Thalassiosira weissflogii: exploring the selective hydrolysis of CO2 and CS2 through rational mutagenesis

16,45-17,00

Y4

Alessandro Bonardi
Dual cholinesterase and carbonic anhydrase inhibitors for a multi-target approach to treat Alzheimer’s disease

17,00-17,15

Y5

Annachiara Sarnella
Targeting CA IX to overcome hypoxia-induced chemoresistance

17,15-17,30

Y6

Wagdy Eldehna
Bioisosteric replacement of SLC-0111 tail with privileged heterocycles to afford novel anticancer agents

20,00

SOCIAL DINNER

Friday, July 7th

SESSION III

Chair: Claudiu T. Supuran

9,00-9,30

K8

Marc Ilies
Novel lipophilic CA IX inhibitors as efficient therapeutic agents for ovarian cancer

9,30-9,50

O12

Silvia Fossati
Inhibiting carbonic anhydrases ameliorates Alzheimer’s disease pathology by restoring cerebrovascular function and reducing inflammation

9,50-10,10

O13

Marianna Patrauchan
Understanding functional roles of β- and γ-Carbonic anhydrases in Pseudomonas aeruginosa

10,10-10,30

O14

Raivis Zalubovskis
From natural product inspired to artificial design of carbonic anhydrase inhibitors

10,30-11,00

COFFEE BREAK

Chairs: Marc Ilies and Raivis Zalubovskis

11,00-11,30

K9

Clemente Capasso
Links between carbonic anhydrase and bacterial metabolism: an opportunity to discover antibacterials

11,30-12,00

K10

William Alexander Donald
Effects of phosphorylation on the activity, inhibition and stability of carbonic anhydrases

12,00-12,20

O15

Ashok Aspatwar
Bicarbonate and bacteria: friends or foes?

12,20-12,40

O16

Hany Ibrahim
Flexible and non-flexible linkers between Zn binding group and tail scaffold in tumor-associated CA inhibitors: a cumulative study

12,40-15,00

LUNCH

YOUNG SESSION II

Chairs: Simone Carradori and Emma Langella

15,00-15,15

Y7

Vincenzo Massimiliano Vivenzio
Unveiling the secrets of γ-carbonic anhydrases in Pseudomonas aeruginosa: structural and biochemical discoveries

15,15-15,30

Y8

Andrea Angeli
Inhibition of carbonic anhydrases as a potential strategy for neuropathic pain management

15,30-15,45

Y9

Paolo Guglielmi
Coumalic acid derivatives as selective inhibitors of human carbonic anhydrase IX and XII: design, synthesis, biological and molecular modeling studies

15,45-16,00

Y10

Sara Amiranda
Loss-of-function analysis of carbonic anhydrase IX in neuronal models

16,00-16,30

COFFEE BREAK

Chairs: Martina Buonanno and Alessio Nocentini

16,30-16,45

Y11

Ilaria D’Agostino
Hybridization strategy applied to antimalarial drug design: towards Artesunate derivatives as inhibitors of P. falciparum carbonic anhydrase

16,45-17,00

Y12

Damiano Tanini
Carbonic anhydrase modulation and glutathione peroxidase imitation: mechanistic insights into the dual activity of chalcogen-containing small molecules

17,00-17,15

Y13

Simone Giovannuzzi
Development of oxazolidinone-based carbonic anhydrase inhibitors as novel antibiotics against gram-positive bacteria

17,15-17,30

YOUNG AND POSTER SESSION AWARDS

17,30-17,40

Conclusive remarks by Giuseppina De Simone and Claudiu T. Supuran